Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties

Chandrasekhar R. Kothapalli; Montgomery T. Shaw; Mei Wei

doi:10.1016/j.actbio.2005.06.005

Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties

Chandrasekhar R. Kothapalli
, Montgomery T. Shaw
, Mei Wei

University of Connecticut

Research output: Contribution to journal › Article › peer-review

Abstract

Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25 nm in width and 150 nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50 wt%, the compression modulus of the scaffolds increased from 4.72 ± 1.2 to 9.87 ± 1.8 MPa, while the yield strength from 0.29 ± 0.03 to 0.44 ± 0.01 MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. © 2005 Actabio Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Original language	American English
Journal	Acta Biomaterialia
Volume	1
DOIs	https://doi.org/10.1016/j.actbio.2005.06.005
State	Published - Nov 1 2005
Externally published	Yes

Keywords

Hydroxyapatite
Mechanical strength
Poly(lactic acid)
Porous scaffolds

Disciplines

Chemical Engineering

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10.1016/j.actbio.2005.06.005License: CC BY

https://doi.org/10.1016/j.actbio.2005.06.005

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@article{fc91e590805a4d149fe3a0fac5f8bf38,

title = "Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties",

abstract = " Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25 nm in width and 150 nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50 wt\%, the compression modulus of the scaffolds increased from 4.72 ± 1.2 to 9.87 ± 1.8 MPa, while the yield strength from 0.29 ± 0.03 to 0.44 ± 0.01 MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. {\textcopyright} 2005 Actabio Materialia Inc. Published by Elsevier Ltd. All rights reserved.",

keywords = "Hydroxyapatite, Mechanical strength, Poly(lactic acid), Porous scaffolds",

author = "Kothapalli, \{Chandrasekhar R.\} and Shaw, \{Montgomery T.\} and Mei Wei",

year = "2005",

month = nov,

day = "1",

doi = "10.1016/j.actbio.2005.06.005",

language = "American English",

volume = "1",

journal = "Acta Biomaterialia",

}

TY - JOUR

T1 - Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties

AU - Kothapalli, Chandrasekhar R.

AU - Shaw, Montgomery T.

AU - Wei, Mei

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25 nm in width and 150 nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50 wt%, the compression modulus of the scaffolds increased from 4.72 ± 1.2 to 9.87 ± 1.8 MPa, while the yield strength from 0.29 ± 0.03 to 0.44 ± 0.01 MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. © 2005 Actabio Materialia Inc. Published by Elsevier Ltd. All rights reserved.

AB - Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25 nm in width and 150 nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50 wt%, the compression modulus of the scaffolds increased from 4.72 ± 1.2 to 9.87 ± 1.8 MPa, while the yield strength from 0.29 ± 0.03 to 0.44 ± 0.01 MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. © 2005 Actabio Materialia Inc. Published by Elsevier Ltd. All rights reserved.

KW - Hydroxyapatite

KW - Mechanical strength

KW - Poly(lactic acid)

KW - Porous scaffolds

UR - https://engagedscholarship.csuohio.edu/encbe_facpub/195

UR - https://doi.org/10.1016/j.actbio.2005.06.005

U2 - 10.1016/j.actbio.2005.06.005

DO - 10.1016/j.actbio.2005.06.005

M3 - Article

VL - 1

JO - Acta Biomaterialia

JF - Acta Biomaterialia

ER -

Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties

Abstract

Keywords

Disciplines

Access to Document

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