Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Norah J. Alghamdi; Lakshmi Balaraman; Kylin A. Emhoff; Ahmed M.H. Salem; Ruhan Wei; Aimin Zhou; W. Christropher Boyd

doi:10.1021/acsomega.9b01684

Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Norah J. Alghamdi
, Lakshmi Balaraman
, Kylin A. Emhoff
, Ahmed M.H. Salem
, Ruhan Wei
, Aimin Zhou
, W. Christropher Boyd

Cleveland State University

Research output: Contribution to journal › Article › peer-review

Abstract

The cobalt(II) complex salts [Co(bpy)(az) ₂ ](PF ₆ ) ₂ and [Co(az) ₄ ](PF ₆ ), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

Original language	American English
Journal	ACS Omega
Volume	4
DOIs	https://doi.org/10.1021/acsomega.9b01684
State	Published - Sep 10 2019

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Chemistry

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Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEFinal published version, 1.38 MBLicense: CC BY

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title = "Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells",

abstract = " The cobalt(II) complex salts [Co(bpy)(az) 2 ](PF 6 ) 2 and [Co(az) 4 ](PF 6 ), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.",

author = "Alghamdi, \{Norah J.\} and Lakshmi Balaraman and Emhoff, \{Kylin A.\} and Salem, \{Ahmed M.H.\} and Ruhan Wei and Aimin Zhou and Boyd, \{W. Christropher\}",

year = "2019",

month = sep,

day = "10",

doi = "10.1021/acsomega.9b01684",

language = "American English",

volume = "4",

journal = "ACS Omega",

}

TY - JOUR

T1 - Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

AU - Alghamdi, Norah J.

AU - Balaraman, Lakshmi

AU - Emhoff, Kylin A.

AU - Salem, Ahmed M.H.

AU - Wei, Ruhan

AU - Zhou, Aimin

AU - Boyd, W. Christropher

PY - 2019/9/10

Y1 - 2019/9/10

N2 - The cobalt(II) complex salts [Co(bpy)(az) 2 ](PF 6 ) 2 and [Co(az) 4 ](PF 6 ), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

AB - The cobalt(II) complex salts [Co(bpy)(az) 2 ](PF 6 ) 2 and [Co(az) 4 ](PF 6 ), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

UR - https://engagedscholarship.csuohio.edu/scichem_facpub/516

U2 - 10.1021/acsomega.9b01684

DO - 10.1021/acsomega.9b01684

M3 - Article

VL - 4

JO - ACS Omega

JF - ACS Omega

ER -

Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

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