Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments

Ioannis K. Zervantonakis; Chandrasekhar R. Kothapalli; Seok Chung; Ryo Sudo; Roger D. Kamm

doi:10.1063/1.3553237

Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments

Ioannis K. Zervantonakis, Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, Roger D. Kamm

Research output: Contribution to journal › Article › peer-review

Abstract

Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. © 2011 American Institute of Physics.

Original language	American English
Journal	Biomicrofluidics
Volume	5
DOIs	https://doi.org/10.1063/1.3553237
State	Published - Jan 1 2011
Externally published	Yes

Disciplines

Chemical Engineering

Access to Document

10.1063/1.3553237License: CC BY

https://doi.org/10.1063/1.3553237

Cite this

@article{43f25c7df52c49cf82e19e65d51aa6d1,

title = "Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments",

abstract = " Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. {\textcopyright} 2011 American Institute of Physics.",

author = "Zervantonakis, \{Ioannis K.\} and Kothapalli, \{Chandrasekhar R.\} and Seok Chung and Ryo Sudo and Kamm, \{Roger D.\}",

year = "2011",

month = jan,

day = "1",

doi = "10.1063/1.3553237",

language = "American English",

volume = "5",

journal = "Biomicrofluidics",

}

TY - JOUR

T1 - Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments

AU - Zervantonakis, Ioannis K.

AU - Kothapalli, Chandrasekhar R.

AU - Chung, Seok

AU - Sudo, Ryo

AU - Kamm, Roger D.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. © 2011 American Institute of Physics.

AB - Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. © 2011 American Institute of Physics.

UR - https://engagedscholarship.csuohio.edu/encbe_facpub/213

UR - https://doi.org/10.1063/1.3553237

U2 - 10.1063/1.3553237

DO - 10.1063/1.3553237

M3 - Article

VL - 5

JO - Biomicrofluidics

JF - Biomicrofluidics

ER -

Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments

Abstract

Disciplines

Access to Document

Other files and links

Cite this