TY - JOUR
T1 - Recent Developments in Carbohydrate-Decorated Targeted Drug/Gene Delivery
AU - Zhang, Hailong
AU - Ma, Yong
AU - Sun, Xue-Long
N1 - Zhang, H.; Ma, Y.; Sun, X. Recent developments in carbohydrate-decorated targeted drug/gene delivery. Med. Res. Rev. 2010, 30, 270-289.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug or gene, and by targeting the drug/gene carrier to specific cell or tissue with the help of specific targeting ligand. The emergence of glycobiology, glycotechnology, and glycomics and their continual adaptation by pharmaceutical scientists have opened exciting avenue of medicinal applications of carbohydrates. Among them, the biocompatibility and specific receptor recognition ability confer the ability of carbohydrates as potential targeting ligands for targeted drug and gene delivery applications. This review summarizes recent progress of carbohydrate-decorated targeted drug/gene delivery applications. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 270–289, 2010
AB - Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug or gene, and by targeting the drug/gene carrier to specific cell or tissue with the help of specific targeting ligand. The emergence of glycobiology, glycotechnology, and glycomics and their continual adaptation by pharmaceutical scientists have opened exciting avenue of medicinal applications of carbohydrates. Among them, the biocompatibility and specific receptor recognition ability confer the ability of carbohydrates as potential targeting ligands for targeted drug and gene delivery applications. This review summarizes recent progress of carbohydrate-decorated targeted drug/gene delivery applications. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 270–289, 2010
KW - glycotargeting; drug delivery; gene delivery; carbohydrate; lectin
UR - https://engagedscholarship.csuohio.edu/scichem_facpub/58
UR - http://onlinelibrary.wiley.com/doi/10.1002/med.20171/abstract
U2 - 10.1002/med.20171
DO - 10.1002/med.20171
M3 - Article
VL - 30
JO - Medicinal Research Reviews
JF - Medicinal Research Reviews
ER -