TY - JOUR
T1 - Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
AU - Farrell, Kurt
AU - Kothapalli, Chandrasekhar R.
N1 - Farrell K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102
PY - 2012/10/20
Y1 - 2012/10/20
N2 - During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
AB - During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
KW - Motor neurons; Growth factors; Extracellular matrix; Animal models; Tissue engineering; Regenerative medicine; Drug delivery; Central nervous system
UR - https://engagedscholarship.csuohio.edu/encbe_facpub/188
UR - https://www.scitechnol.com/tissue-engineering-approaches-for-motor-neuron-pathway-regeneration-iocx.php?article_id=350
U2 - 10.4172/2325-9620.1000102
DO - 10.4172/2325-9620.1000102
M3 - Article
VL - 1
JO - Journal of Regenerative Medicine
JF - Journal of Regenerative Medicine
ER -