Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

Kurt Farrell; Chandrasekhar R. Kothapalli

doi:10.4172/2325-9620.1000102

Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

Kurt Farrell
, Chandrasekhar R. Kothapalli

Cleveland State University

Research output: Contribution to journal › Article › peer-review

Abstract

During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.

Original language	American English
Journal	Journal of Regenerative Medicine
Volume	1
DOIs	https://doi.org/10.4172/2325-9620.1000102
State	Published - Oct 20 2012

Keywords

Motor neurons; Growth factors; Extracellular matrix; Animal models; Tissue engineering; Regenerative medicine; Drug delivery; Central nervous system

Disciplines

Biochemical and Biomolecular Engineering
Molecular, Cellular, and Tissue Engineering

Access to Document

10.4172/2325-9620.1000102License: CC BY

https://www.scitechnol.com/tissue-engineering-approaches-for-motor-neuron-pathway-regeneration-iocx.php?article_id=350

Cite this

@article{e763782adb8c41dbb0efe6ed48a50219,

title = "Tissue Engineering Approaches for Motor Neuron Pathway Regeneration",

abstract = " During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.",

keywords = "Motor neurons; Growth factors; Extracellular matrix; Animal models; Tissue engineering; Regenerative medicine; Drug delivery; Central nervous system",

author = "Kurt Farrell and Kothapalli, \{Chandrasekhar R.\}",

note = "Farrell K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102",

year = "2012",

month = oct,

day = "20",

doi = "10.4172/2325-9620.1000102",

language = "American English",

volume = "1",

journal = "Journal of Regenerative Medicine",

}

TY - JOUR

T1 - Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

AU - Farrell, Kurt

AU - Kothapalli, Chandrasekhar R.

N1 - Farrell K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102

PY - 2012/10/20

Y1 - 2012/10/20

N2 - During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.

AB - During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.

KW - Motor neurons; Growth factors; Extracellular matrix; Animal models; Tissue engineering; Regenerative medicine; Drug delivery; Central nervous system

UR - https://engagedscholarship.csuohio.edu/encbe_facpub/188

UR - https://www.scitechnol.com/tissue-engineering-approaches-for-motor-neuron-pathway-regeneration-iocx.php?article_id=350

U2 - 10.4172/2325-9620.1000102

DO - 10.4172/2325-9620.1000102

M3 - Article

VL - 1

JO - Journal of Regenerative Medicine

JF - Journal of Regenerative Medicine

ER -

Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Cite this